Jud Coon: 35 years of p450 research, a synopsis of p450 history.

The 1996 Bernard B. Brodie lecture: A journey in cytochrome P450 and drug metabolism research.

I am very honored at being chosen as the recipient of the 1996 Bernard B. Brodie Award in Drug Metabolism and to join the ranks of the previous recipients of the award (Gillette, 1979; Coon, 1981; Jerina, 1983; Mannering, 1986; Nebert, 1986; Levin, 1990; Zeigler, 1991; Guengerich, 1993; Ortiz de Montellano, 1995). I wish to thank the American Society for Pharmacology and Experimental Therapeuti...

Cloning and gene expression of cytochrome P450 gene from Alcanivorax borkumensis Bacterium

Alcanivorax borkumensis is a marine bacterium that has ability to grow on limited substrates that mainly is alkanes. The ability to use wide range of hydrocarbons is advantage of this bacterium to other marine community bacteria. A. borkumensis have two genetic systems for alkane biodegradation. The First system is alkane hydroxylase (alk-B1and alk-B2) and the second system is...

Cloning and gene expression of cytochrome P450 gene from Alcanivorax borkumensis Bacterium

Alcanivorax borkumensis is a marine bacterium that has ability to grow on limited substrates that mainly is alkanes. The ability to use wide range of hydrocarbons is advantage of this bacterium to other marine community bacteria. A. borkumensis have two genetic systems for alkane biodegradation. The First system is alkane hydroxylase (alk-B1and alk-B2) and the second system is...

A preliminary study on the expression level of P450 gene in liver and gill tissues of Persian sturgeon (Acipenser persicus Borodin, 1987) exposed to water soluble fractions of crude oil

The present study was conducted to investigate the expression level of cytochrome P450 enzyme in detoxification of water soluble fractions (WSFs) of crude oil in Persian sturgeon, Acipenser persicus. Fish were exposed to WSFs at concentrations of 0 (control), 10, 20, and 50% of the LC50 for 14 days, and then, the expression level of P450 gene was assayed in gill and liver samples. According to ...

Destructive effect of quinone-containing compounds on cytochrome P450: Arbutin as a double-edged sword